Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.47 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14287158 | 0.90 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8537048 | 0.90 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4TNKS | |
| SCHEMBL8533969 | 0.82 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL14287157 | 0.79 | GRIA1 (0.46) | GRIA1GRIA2GRIA3GRIA4TNKS | |
| SCHEMBL6787042 | 0.75 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL6785459 | 0.75 | GRIA1 (0.57) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7103934 | 0.70 | GRIA1 (0.81) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL6784941 | 0.70 | GRIA1 (0.48) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL6783750 | 0.70 | GRIA1 (0.48) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6783751 | 0.70 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0698025-B1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH AS (DK) | 1997-12-17 | — | — | EP | disclosed |
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |