Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 10/20 | 0.47 |
| ▸ | MLNR | O43193 | 5/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153134 | 0.82 | GLA (0.45) | GHSRMLNRGLASMN1; SMN2 | |
| SCHEMBL18577233 | 0.81 | SMN1; SMN2 (0.44) | CYP2C19GHSRMLNRGLACYP3A4 | |
| SCHEMBL18577231 | 0.81 | SMN1; SMN2 (0.44) | CYP2C19GHSRMLNRGLACYP3A4 | |
| SCHEMBL6936657 | 0.81 | GLA (0.58) | GHSRGLA | |
| SCHEMBL9437533 | 0.81 | GLA (0.58) | GHSRGLA | |
| SCHEMBL9437531 | 0.81 | GLA (0.58) | GHSRGLA | |
| SCHEMBL7647043 | 0.77 | MLNR (0.46) | GHSRMLNRGLASMN1; SMN2 | |
| SCHEMBL13876425 | 0.72 | MLNR (0.53) | MAPTMLNRGLASMN1; SMN2 | |
| SCHEMBL25365707 | 0.71 | KDM4E (0.48) | CYP2C19MAPTCYP2C9GHSRGLA | |
| SCHEMBL7452857 | 0.71 | SMN1; SMN2 (0.42) | CYP2C19MAPTCYP2C9GHSRGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739334-A | CHEMICAL INTERMEDIATES FOR NEW ANTIDEPRESSANT WITH SIDE EFFECT REDUCTION | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1998-04-14 | — | — | US | disclosed |
| US-5726178-A | Alkyl derivatives of trazodone with CNS activity | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1998-03-10 | — | — | US | disclosed |
| US-5543563-A | ANTIDEPRESSANTS; SIDE EFFECT REDUCTION | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1996-08-06 | — | — | US | disclosed |
| EP-0623131-B1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY | ANGELINI RICERCHE SPA (IT) | 1996-04-03 | — | — | EP | disclosed |
| EP-0623131-A1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY. | ANGELINI FRANCESCO IST RICERCA (IT) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014091-A1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1993-07-22 | — | — | WO | disclosed |