SCHEMBL8534374

SCHEMBL8534374

O=C(OCc1ccccc1)C(Cl)Cl

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.64
TDP1 Q9NUW8 2/20 0.57
MAPK1 P28482 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
SLC6A2 P23975 1/20 0.57
SLC6A3 Q01959 1/20 0.57
KMT2A Q03164 1/20 0.57
LMNA P02545 3/20 0.52
HCAR2 Q8TDS4 1/20 0.52
ELANE P08246 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.47
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA9 Q16790 1/20 0.47
AKR1B1 P15121 1/20 0.46
CTRB1 P17538 2/20 0.46
POLB P06746 1/20 0.46
CDC25B P30305 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29079450 0.87 ALDH1A1 (0.61) ALDH1A1TDP1MAPK1L3MBTL1SLC6A2
SCHEMBL8784388 0.84 ALDH1A1 (0.60) ALDH1A1TDP1MAPK1L3MBTL1SLC6A2
SCHEMBL1705376 0.84 ALDH1A1 (0.60) ALDH1A1TDP1MAPK1L3MBTL1SLC6A2
SCHEMBL9557590 0.84 ALDH1A1 (0.60) ALDH1A1TDP1MAPK1L3MBTL1SLC6A2
SCHEMBL18328108 0.84 ALDH1A1 (0.60) ALDH1A1TDP1MAPK1L3MBTL1SLC6A2
SCHEMBL2016551 0.84 ALDH1A1 (0.60) ALDH1A1TDP1MAPK1L3MBTL1SLC6A2
SCHEMBL394346 0.83 ALDH1A1 (0.63) ALDH1A1TDP1MAPK1L3MBTL1SLC6A2
SCHEMBL11384010 0.82 ALDH1A1 (0.58) ALDH1A1TDP1MAPK1L3MBTL1SLC6A2
SCHEMBL10399514 0.82 ALDH1A1 (0.58) ALDH1A1TDP1MAPK1L3MBTL1SLC6A2
SCHEMBL9557702 0.82 ALDH1A1 (0.58) ALDH1A1TDP1MAPK1L3MBTL1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105646757-B A kind of preparation method of cationic polymerization system and high degree of unsaturation isoolefin copolymers 中国石油化工股份有限公司 2018-04-13 CN claimed
CN-105646757-A Cationic polymerization system and preparation method of high-unsaturation-degree isoolefin copolymer 中国石油化工股份有限公司 2016-06-08 CN claimed
CN-103420836-A Purifying method of fluorine-containing low-carbon aliphatic acid BIOTALK CO LTD 2013-12-04 CN claimed
EP-4568961-A1 PROCESSES FOR PREPARING OXAZOLIDINONE COMPOUNDS Merck Sharp & Dohme LLC (US) 2025-06-18 EP disclosed
CN-116023544-B Catalyst component for olefin polymerization, preparation method thereof, catalyst and olefin polymerization method 中国石油化工股份有限公司 2024-12-06 CN disclosed
CN-116023542-B Catalyst component, catalyst and preparation method and application thereof 中国石油化工股份有限公司 2024-09-17 CN disclosed
WO-2024035618-A1 PROCESSES FOR PREPARING OXAZOLIDINONE COMPOUNDS MERCK SHARP & DOHME LLC (US) 2024-02-15 WO disclosed
EP-4126819-A1 7- OR 8-HYDROXY-ISOQUINOLINE AND 7- OR 8-HYDROXY-QUINOLINE DERIVATIVES AS ALPHA-1 -ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1 -ANTITRYPSIN DEFICIENCY (AATD) Vertex Pharmaceuticals Incorporated (US) 2023-02-08 EP disclosed
CN-105646757-B A kind of preparation method of cationic polymerization system and high degree of unsaturation isoolefin copolymers 中国石油化工股份有限公司 2018-04-13 CN disclosed
CN-105646757-A Cationic polymerization system and preparation method of high-unsaturation-degree isoolefin copolymer 中国石油化工股份有限公司 2016-06-08 CN disclosed
CN-103420825-A Synthetic method of difluoroacetate BIOTALK CO LTD 2013-12-04 CN disclosed
EP-0504612-B1 Novel 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them AMERICAN CYANAMID CO (US) 1998-01-21 EP disclosed
US-5700930-A 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them AMERICAN CYANAMID COMPANY (US) 1997-12-23 US disclosed
CN-1166489-A Prep. of novel alkyl-substituted alpha-ketone ester AMERICAN CYANAMID CO (US) 1997-12-03 CN disclosed
US-5656753-A 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them AMERICAN CYANAMID COMPANY (US) 1997-08-12 US disclosed
US-5371215-A 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them AMERICAN CYANAMID COMPANY (US) 1994-12-06 US disclosed
US-5189158-A 4-SUBSTITUTED AZETIDINONES AS PRECURSORS TO 2-SUBSTITUTED-3-CARBOXY CARBAPENEM ANTIBIOTICS AND A METHOD OF PRODUCING THEM AMERICAN CYANAMID COMPANY (US) 1993-02-23 US disclosed
CN-1065061-A Novel 4-substituted azetidinones as precursors to 2-substituted-3-carboxycarbapenem antibiotics and processes for their preparation AMERICAN CYANAMID CO (US) 1992-10-07 CN disclosed
EP-0504612-A2 Novel 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them AMERICAN CYANAMID COMPANY (US) 1992-09-23 EP disclosed
EP-0080286-A1 Antibacterial compounds containing beta-lactams, processes for their preparation and their use BEECHAM GROUP PLC (GB) 1983-06-01 EP disclosed