Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8532976 | 0.91 | KLKB1 (0.53) | KLKB1TSHRCACNA1HCACNA1GCACNA1I | |
| SCHEMBL18987207 | 0.88 | KLKB1 (0.44) | KLKB1L3MBTL1GCGRABL1PDE2A | |
| SCHEMBL18987058 | 0.87 | KLKB1 (0.52) | KLKB1CACNA1HCACNA1GCACNA1IGRIN1 | |
| SCHEMBL2819900 | 0.87 | KLKB1 (0.56) | KLKB1TSHRCACNA1HCACNA1GCACNA1I | |
| SCHEMBL2511099 | 0.85 | L3MBTL1 (0.56) | KLKB1GRIN1GRIN2BL3MBTL1HSD17B10 | |
| SCHEMBL27844387 | 0.82 | MAPT (0.56) | KLKB1GRIN1GRIN2BALDH1A1HSD17B10 | |
| SCHEMBL21910761 | 0.81 | MAPT (0.45) | KLKB1GRIN1GRIN2BL3MBTL1ALDH1A1 | |
| SCHEMBL20250854 | 0.79 | CREBBP (0.54) | KLKB1GRIN1GRIN2BL3MBTL1ALDH1A1 | |
| SCHEMBL2509415 | 0.78 | L3MBTL1 (0.52) | KLKB1GRIN1GRIN2BL3MBTL1 | |
| SCHEMBL19002057 | 0.78 | KLKB1 (0.48) | KLKB1TSHRAADATALDH1A1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |