Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6670085 | 0.83 | OPRM1 (0.37) | KMT2AALDH1A1PKMOPRM1AKR1B1 | |
| SCHEMBL8538861 | 0.83 | SMN1; SMN2 (0.45) | KMT2AMEN1 | |
| SCHEMBL10237752 | 0.81 | PBRM1 (0.38) | PBRM1AROPRM1 | |
| SCHEMBL9932579 | 0.74 | PBRM1 (0.40) | PBRM1ARKMT2AMEN1ALDH1A1 | |
| SCHEMBL8535428 | 0.74 | PBRM1 (0.40) | PBRM1ARKMT2AMEN1ALDH1A1 | |
| SCHEMBL7674281 | 0.73 | KDR (0.33) | PKM | |
| SCHEMBL9882137 | 0.71 | BACE1 (0.38) | PBRM1ARKMT2AMEN1CYP19A1 | |
| SCHEMBL8534011 | 0.71 | BACE1 (0.38) | PBRM1ARKMT2AMEN1CYP19A1 | |
| SCHEMBL8534008 | 0.71 | BACE1 (0.38) | PBRM1ARKMT2AMEN1CYP19A1 | |
| SCHEMBL9932272 | 0.70 | DRD4 (0.41) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012071458-A1 | HETEROCYCLIC INHIBITORS OF BETA - SECRETASE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2012-05-31 | — | — | WO | disclosed |