SCHEMBL8535452

SCHEMBL8535452

COC(=O)C(C)Oc1cccnc1SC(C)C

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
F9 P00740 1/20 0.39
PLAU P00749 1/20 0.39
KMT2A Q03164 3/20 0.39
HSD17B10 Q99714 1/20 0.38
FFAR4 Q5NUL3 1/20 0.38
ALDH1A1 P00352 4/20 0.37
KDM4E B2RXH2 3/20 0.37
SMN1; SMN2 Q16637 4/20 0.37
POLB P06746 2/20 0.37
TP53 P04637 1/20 0.37
MEN1 O00255 1/20 0.37
MAPT P10636 1/20 0.37
RAB9A P51151 1/20 0.36
NOTUM Q6P988 1/20 0.36
USP2 O75604 1/20 0.36
LMNA P02545 1/20 0.36
HTT P42858 1/20 0.36
PKM P14618 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29142427 0.78 F9 (0.41) F9PLAUKMT2AALDH1A1KDM4E
SCHEMBL30640694 0.78 F9 (0.41) F9PLAUKMT2AALDH1A1KDM4E
SCHEMBL29142428 0.78 F9 (0.41) F9PLAUKMT2AALDH1A1KDM4E
SCHEMBL9023974 0.76 ALOX5AP (0.37) KMT2AFFAR4KDM4EPOLBMEN1
SCHEMBL15818865 0.76 POLB (0.59) KMT2AALDH1A1KDM4ESMN1; SMN2POLB
SCHEMBL5792686 0.76 POLB (0.59) KMT2AALDH1A1KDM4ESMN1; SMN2POLB
SCHEMBL5792452 0.76 POLB (0.59) KMT2AALDH1A1KDM4ESMN1; SMN2POLB
SCHEMBL8537336 0.75 FFAR4 (0.37) KMT2AHSD17B10FFAR4ALDH1A1SMN1; SMN2
SCHEMBL6313497 0.75 F9 (0.50) F9PLAUKMT2AHSD17B10SMN1; SMN2
SCHEMBL5757213 0.75 F9 (0.50) F9PLAUKMT2AHSD17B10SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0540697-B1 SULFONYLUREAS CIBA GEIGY AG (CH) 1998-06-03 EP disclosed
US-5625071-A HERBICIDES CIBA-GEIGY CORPORATION (US) 1997-04-29 US disclosed
US-5403814-A Preemergence and postemergence herbicides CIBA-GEIGY CORPORATION (US) 1995-04-04 US disclosed
EP-0540697-A1 NOVEL SULFONYLUREAS Novartis AG (CH) 1993-05-12 EP disclosed
WO-1992016522-A1 NOVEL SULFONYLUREAS CIBA-GEIGY AG (CH) 1992-10-01 WO disclosed