Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166634 | 1.00 | KMT2A (0.55) | KMT2AALDH1A1P2RX7GAAUSP2 | |
| SCHEMBL28663248 | 0.88 | FKBP1A (0.53) | KMT2AP2RX7CAPN1HDAC1HDAC6 | |
| SCHEMBL21869824 | 0.88 | FKBP1A (0.53) | KMT2AP2RX7CAPN1HDAC1HDAC6 | |
| SCHEMBL6997222 | 0.87 | GAA (0.58) | KMT2AALDH1A1P2RX7GAACYP2C9 | |
| SCHEMBL21869747 | 0.86 | KMT2A (0.62) | KMT2AALDH1A1GAACYP3A4CYP2C9 | |
| SCHEMBL21869798 | 0.86 | KMT2A (0.62) | KMT2AALDH1A1GAACYP3A4CYP2C9 | |
| SCHEMBL28663232 | 0.86 | KMT2A (0.62) | KMT2AALDH1A1GAACYP3A4CYP2C9 | |
| SCHEMBL24434796 | 0.86 | KMT2A (0.57) | KMT2AALDH1A1P2RX7GAACYP3A4 | |
| SCHEMBL927807 | 0.86 | KMT2A (0.57) | KMT2AALDH1A1P2RX7GAACYP3A4 | |
| SCHEMBL2583749 | 0.86 | KMT2A (0.57) | KMT2AALDH1A1P2RX7GAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817651-A | ANALGESICS, RHEUMATIC DISEASES, ANTIINFLAMMATORY AGENTS | SANOFI (FR) | 1998-10-06 | — | — | US | disclosed |
| US-5607933-A | METHODS FOR TREATMENT OF GLAUCOMA AND FOR RELIEF OF PAIN AND RHEUMATIC AND INFLAMMATORY CONDITIONS BY ADMINISTERING THE INDOLES; N-HETERYL IS 2-PIPERAZINYL | STERLING WINTHROP INC. (US) | 1997-03-04 | — | — | US | disclosed |
| US-5068234-A | Analgesics, rheumatic diseases, antiinflammatory agents or antiglaucoma | STERLING DRUG INC. (US) | 1991-11-26 | — | — | US | disclosed |
| EP-0444451-A2 | 3-Arylcarbonyl-1H-indoles useful as therapeutic agents | STERLING WINTHROP INC. (US) | 1991-09-04 | — | — | EP | disclosed |