Fosamine

Fosamine

SCHEMBL8535758

CCOP(=O)(O)C(N)=O.CCOP(=O)(O)C(N)=O

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.43
PPARD Q03181 2/20 0.43
ALOX15 P16050 1/20 0.40
TP53 P04637 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
TPI1 P60174 1/20 0.37
CA4 P22748 1/20 0.35
PGD P52209 1/20 0.33
LPAR1 Q92633 1/20 0.32
LPAR3 Q9UBY5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fosamine SCHEMBL64451 1.00
Fosamine SCHEMBL163122 0.98 TSHR (0.42) TSHRPPARDALOX15TP53TDP1
Fosamine SCHEMBL9375441 0.98 TSHR (0.42) TSHRPPARDALOX15TP53TDP1
Fosamine SCHEMBL11740060 0.91 PPARD (0.38) TSHRPPARDALOX15TP53TDP1
Fosamine SCHEMBL11742074 0.89 SAT1 (0.37) TSHRPPARDALOX15TP53TDP1
Fosamine SCHEMBL11882271 0.88 PPARD (0.35) TSHRPPARDALOX15TP53TDP1
Fosamine SCHEMBL11742086 0.83 CA12 (0.40) TSHRPPARDCA12CA1CA2
Fosamine SCHEMBL11742068 0.82 CA12 (0.32) TSHRPPARDCA12CA1CA2
Fosamine SCHEMBL11740910 0.80 MEN1 (0.34) TSHRPPARD
Glyphosate SCHEMBL9271349 0.79 EGLN1 (0.31) PPARDCA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0574418-B1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1998-11-11 EP disclosed
US-5688745-A Arylsulfonylureas and their use as herbicides and growth regulators HOECHST AKTIENGESELLSCHAFT (DE) 1997-11-18 US disclosed
US-5463081-A Chemical intermediates HOECHST AKTIENGESELLSCHAFT (DE) 1995-10-31 US disclosed
EP-0574418-A1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS Hoechst Schering AgrEvo GmbH (DE) 1993-12-22 EP disclosed
WO-1992013845-A1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST AKTIENGESELLSCHAFT (DE) 1992-08-20 WO disclosed