Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.74 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2573862 | 0.87 | BACE1 (0.70) | BACE1BACE2CTSD | |
| SCHEMBL8538563 | 0.85 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL8534411 | 0.85 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL16487863 | 0.84 | BACE1 (0.54) | BACE1CTSD | |
| Formic Acid SCHEMBL2560041 | 0.78 | BACE1 (0.58) | BACE1BACE2CTSD | |
| SCHEMBL2574295 | 0.78 | BACE1 (0.61) | BACE1BACE2CTSD | |
| SCHEMBL7711676 | 0.76 | BACE1 (0.78) | BACE1BACE2CTSD | |
| SCHEMBL2571375 | 0.76 | BACE1 (0.51) | BACE1CTSD | |
| SCHEMBL7710636 | 0.75 | BACE1 (0.69) | BACE1CTSD | |
| SCHEMBL16487873 | 0.74 | BACE1 (1.00) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957083-B2 | Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2015-02-17 | — | — | US | disclosed |
| EP-2643325-A1 | SPIRO-AMINO-IMIDAZOLONE AND SPIRO-AMINO-DIHYDRO-PYRIMIDINONE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012071279-A1 | SPIRO-AMINO-IMIDAZOLONE AND SPIRO-AMINO-DIHYDRO-PYRIMIDINONE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2012-05-31 | — | — | WO | disclosed |