Carbromal

Carbromal

SCHEMBL8536554

CCC(Br)(CC)C(=O)NC(N)=O.c1ccccc1

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 1/20 0.36
NR3C1 P04150 1/20 0.35
RIPK1 Q13546 3/20 0.33
POLB P06746 1/20 0.31
HDAC3 O15379 1/20 0.31
HDAC4 P56524 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC10 Q969S8 1/20 0.31
HDAC11 Q96DB2 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
HDAC9 Q9UKV0 1/20 0.31
HDAC5 Q9UQL6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbromal SCHEMBL6249616 0.98 CRBN (0.37) CRBNNR3C1RIPK1
Carbromal SCHEMBL5178580 0.96 CRBN (0.36) CRBNNR3C1RIPK1
Carbromal SCHEMBL261 0.96 CRBN (0.39) CRBNNR3C1
Carbromal SCHEMBL15057476 0.96 CRBN (0.39) CRBNNR3C1
Carbromal SCHEMBL4351621 0.96 CRBN (0.39) CRBNNR3C1
Carbromal SCHEMBL3683634 0.94 CRBN (0.34) CRBNNR3C1
Carbromal SCHEMBL8429924 0.94 CRBN (0.37) CRBNNR3C1
Carbromal SCHEMBL14637724 0.94 CRBN (0.37) CRBNNR3C1
Carbromal SCHEMBL4352660 0.94 CRBN (0.37) CRBNNR3C1
Carbromal SCHEMBL1537494 0.94 CRBN (0.37) CRBNNR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100491326-C 3-hydroxy olefine acid derivative and its preparation and application CHINESE ACAD INST CHEMISTRY (CN) 2009-05-27 CN disclosed
CN-101020639-A 3-hydroxy olefine acid derivative and its prepn and application CHINESE ACAD INST CHEMISTRY (CN) 2007-08-22 CN disclosed
US-5851243-A Radiographic elements capable of rapid access processing modified to reduce red light transmission EASTMAN KODAK COMPANY (US) 1998-12-22 US disclosed
US-5744294-A POLYMERIC DYES SELECTED FROM A POLYESTER FORMED FROM PHTHALOCYANINE HYDROXYNEOPENTYLSULFOMYL AND/OR ANTHRAQUINONE HYDROXYETHYLSUFAMOYL DERIVATIVES WITH DICARBOXYLIC ACIDS AND SULFOSUBSTITUTED DICARBOXYLIC ACIDS; BLUE TINT EASTMAN KODAK COMPANY (US) 1998-04-28 US disclosed
US-5716769-A RADIOGRAPHIC ELEMENTS EASTMAN KODAK COMPANY (US) 1998-02-10 US disclosed
US-4302403-A OBVIATING NEED TO REMOVE WATER PRODUCED KOPPERS COMPANY, INC. (US) 1981-11-24 US disclosed