Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 16/20 | 0.67 |
| ▸ | CTRC | Q99895 | 3/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445689 | 0.88 | ELANE (0.60) | ELANECTRCCASP1PTPN1CASP3 | |
| SCHEMBL1329615 | 0.87 | ELANE (0.65) | ELANECTRC | |
| SCHEMBL8531683 | 0.87 | ELANE (0.59) | ELANECTRCCASP1PTPN1CASP3 | |
| SCHEMBL2279465 | 0.86 | ELANE (0.58) | ELANECTRCCASP1PTPN1CASP3 | |
| SCHEMBL7276488 | 0.85 | ELANE (0.64) | ELANECTRCCASP1PTPN1NPC1 | |
| SCHEMBL7402310 | 0.85 | ELANE (0.60) | ELANECTRCCASP1PTPN1CASP3 | |
| SCHEMBL21685578 | 0.84 | NPC1 (0.50) | ELANECTRCCASP1PTPN1CASP3 | |
| SCHEMBL7276654 | 0.81 | ELANE (1.00) | ELANECTRC | |
| SCHEMBL8536676 | 0.81 | ELANE (0.59) | ELANECTRC | |
| SCHEMBL7276644 | 0.80 | ELANE (0.76) | ELANECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721222-A | Heterocyclic ketones | ZENECA LIMITED (GB) | 1998-02-24 | — | — | US | disclosed |
| US-5486529-A | Certain pyridyl ketones for treating diseases involving leukocyte elastase | ZENECA LIMITED (GB) | 1996-01-23 | — | — | US | disclosed |