Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 18/20 | 0.59 |
| ▸ | CTRC | Q99895 | 3/20 | 0.59 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276488 | 0.92 | ELANE (0.64) | ELANECTRC | |
| SCHEMBL7446091 | 0.88 | ELANE (0.53) | ELANECTRCMGLL | |
| SCHEMBL7440440 | 0.85 | ELANE (0.55) | ELANECTRCMGLL | |
| SCHEMBL6557728 | 0.85 | ELANE (0.70) | ELANEMGLL | |
| SCHEMBL7282342 | 0.82 | ELANE (0.68) | ELANECTRC | |
| SCHEMBL8536815 | 0.81 | ELANE (0.67) | ELANECTRC | |
| SCHEMBL7442027 | 0.80 | ELANE (0.64) | ELANECTRC | |
| SCHEMBL7276853 | 0.80 | HDAC3 (0.53) | ELANECTRCKDM4EALDH1A1APEX1 | |
| SCHEMBL7283124 | 0.80 | ELANE (0.49) | ELANECTRCHSD17B10 | |
| SCHEMBL21685578 | 0.80 | NPC1 (0.50) | ELANECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636142-B1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1998-06-17 | — | — | EP | disclosed |
| US-5721222-A | Heterocyclic ketones | ZENECA LIMITED (GB) | 1998-02-24 | — | — | US | disclosed |
| US-5486529-A | Certain pyridyl ketones for treating diseases involving leukocyte elastase | ZENECA LIMITED (GB) | 1996-01-23 | — | — | US | disclosed |