SCHEMBL8537235

SCHEMBL8537235

Nc1ncnc2c1ncn2[C@@H]1C[C@H](CO)[C@H]1CO

nearest known ligand 0.75

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
AHCY P23526 14/20 0.75
ADORA2B P29275 2/20 0.75
ADORA3 P0DMS8 1/20 0.56
ADORA2A P29274 1/20 0.56
ADORA1 P30542 1/20 0.56
SLC28A1 O00337 1/20 0.56
SLC28A2 O43868 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6691588 1.00 AHCY (0.75) AHCYADORA2BADORA3ADORA2AADORA1
SCHEMBL8537239 1.00 AHCY (0.75) AHCYADORA2BADORA3ADORA2AADORA1
SCHEMBL9470389 1.00 AHCY (0.75) AHCYADORA2BADORA3ADORA2AADORA1
SCHEMBL8537515 1.00 AHCY (0.75) AHCYADORA2BADORA3ADORA2AADORA1
SCHEMBL1980695 1.00 AHCY (0.75) AHCYADORA2BADORA3ADORA2AADORA1
SCHEMBL15630293 1.00 AHCY (0.75) AHCYADORA2BADORA3ADORA2AADORA1
SCHEMBL2449534 1.00 AHCY (0.75) AHCYADORA2BADORA3ADORA2AADORA1
SCHEMBL10448266 1.00 AHCY (0.75) AHCYADORA2BADORA3ADORA2AADORA1
SCHEMBL9759808 1.00 AHCY (0.75) AHCYADORA2BADORA3ADORA2AADORA1
SCHEMBL15630223 1.00 AHCY (0.75) AHCYADORA2BADORA3ADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0358154-B1 Novel cyclobutane derivative and process for producing same NIPPON KAYAKU KK (JP) 1998-12-02 EP claimed
EP-0335355-B1 Bis-(hydroxymethyl) cyclobutyl purines and pyrimidines SQUIBB & SONS INC (US) 1997-10-01 EP claimed
WO-1990005730-A2 NOVEL CYCLOBUTANE DERIVATIVE AND PROCESS FOR PRODUCING SAME NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1990-05-31 WO claimed
JP-8301766-A None JP disclosed
JP-8301765-A None JP disclosed
WO-2025085233-A1 NOVEL DERIVATIVES OF QUINOLINONES, AND COMPOSITIONS AND METHODS THEREOF ENSEM THERAPEUTICS, INC. (US) 2025-04-24 WO disclosed
CN-119241408-A Trifluoro methyl sulfide molecule as HIF2a inhibitor 维眸生物科技(浙江)有限公司 2025-01-03 CN disclosed
EP-4395889-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING Remix Therapeutics Inc. (US) 2024-07-10 EP disclosed
WO-2024030651-A1 GPX4 INHIBITORS AND USE THEREOF SONATA THERAPEUTICS, INC. (US) 2024-02-08 WO disclosed
WO-2023034833-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2023-03-09 WO disclosed
WO-2023034836-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2023-03-09 WO disclosed
US-5723609-A VIRICIDES E. R. SQUIBB & SONS, INC. (US) 1998-03-03 US disclosed
EP-0335355-B1 Bis-(hydroxymethyl) cyclobutyl purines and pyrimidines SQUIBB & SONS INC (US) 1997-10-01 EP disclosed
JP-H08301766-A ANTIVIRAL AGENT NIPPON KAYAKU CO LTD 1996-11-19 JP disclosed
JP-H08301765-A CARCINOSTATIC NIPPON KAYAKU CO LTD 1996-11-19 JP disclosed
US-5130462-A Intermediates for viricides E. R. SQUIBB & SONS, INC. (US) 1992-07-14 US disclosed
US-5126345-A Viricides E. R. SQUIBB & SONS, INC. (US) 1992-06-30 US disclosed
WO-1990005730-A2 NOVEL CYCLOBUTANE DERIVATIVE AND PROCESS FOR PRODUCING SAME NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1990-05-31 WO disclosed
EP-0358154-A2 Novel cyclobutane derivative and process for producing same NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1990-03-14 EP disclosed
EP-0335355-A2 Bis-(hydroxymethyl) cyclobutyl purines and pyrimidines E.R. Squibb & Sons, Inc. (US) 1989-10-04 EP disclosed