SCHEMBL8537248

SCHEMBL8537248

CSCC(=O)NN=C(c1ccc(Cl)cc1)c1ccc(OS(=O)(=O)C(F)(F)F)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
ALDH1A1 P00352 5/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ENPP1 P22413 4/20 0.38
ENPP3 O14638 3/20 0.38
ENPP2 Q13822 2/20 0.38
MAPT P10636 3/20 0.37
KDM4E B2RXH2 2/20 0.37
GAA P10253 1/20 0.37
CXCR2 P25025 1/20 0.37
PSEN1 P49768 1/20 0.36
PSEN2 P49810 1/20 0.36
APH1B Q8WW43 1/20 0.36
NCSTN Q92542 1/20 0.36
APH1A Q96BI3 1/20 0.36
PSENEN Q9NZ42 1/20 0.36
AKR1C3 P42330 2/20 0.35
AR P10275 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11032656 0.88 MEN1 (0.41) MEN1KMT2AALDH1A1RAB9ASMN1; SMN2
SCHEMBL11032658 0.88 MEN1 (0.41) MEN1KMT2AALDH1A1RAB9ASMN1; SMN2
SCHEMBL8535057 0.86 ALDH1A1 (0.53) MEN1KMT2AALDH1A1RAB9ASMN1; SMN2
SCHEMBL11033152 0.86 ALDH1A1 (0.46) MEN1KMT2AALDH1A1RAB9ASMN1; SMN2
SCHEMBL11033155 0.86 ALDH1A1 (0.46) MEN1KMT2AALDH1A1RAB9ASMN1; SMN2
SCHEMBL9079609 0.84 MEN1 (0.42) MEN1KMT2AALDH1A1SMN1; SMN2ENPP1
SCHEMBL10973313 0.84 MEN1 (0.42) MEN1KMT2AALDH1A1SMN1; SMN2ENPP1
SCHEMBL7104412 0.82 ENPP1 (0.41) MEN1KMT2AALDH1A1ENPP1ENPP3
SCHEMBL7104414 0.82 ENPP1 (0.41) MEN1KMT2AALDH1A1ENPP1ENPP3
SCHEMBL9079636 0.81 SMN1; SMN2 (0.44) MEN1KMT2AALDH1A1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0662472-B1 Hydrazone derivates as pesticides CIBA GEIGY AG (CH) 1998-03-11 EP disclosed
EP-0662472-A1 Hydrazone derivates as pesticides CIBA-GEIGY AG (CH) 1995-07-12 EP disclosed