SCHEMBL8537859

SCHEMBL8537859

CNc1cc(C(N)=O)cc(O)c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.39
GAA P10253 3/20 0.39
ALDH1A1 P00352 2/20 0.39
GLA P06280 1/20 0.39
PARP1 P09874 2/20 0.36
NNMT P40261 2/20 0.36
PRKCI P41743 1/20 0.36
PTPN11 Q06124 2/20 0.36
LCK P06239 1/20 0.35
LMNA P02545 2/20 0.33
POLB P06746 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
NFKB1 P19838 1/20 0.33
XDH P47989 1/20 0.33
GFER P55789 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
FUT7 Q11130 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3113078 0.72 MAPK14 (0.47) KDM4EGAAALDH1A1GLAPARP1
SCHEMBL18471225 0.71 SMN1; SMN2 (0.49) ALDH1A1PARP1NNMTPOLBTDP1
SCHEMBL16281799 0.68 PTPN11 (0.45) KDM4EGAAALDH1A1PARP1PTPN11
SCHEMBL2139 0.68 KDM4E (0.59) KDM4EGAAALDH1A1PARP1PTPN11
SCHEMBL14190740 0.68 PRKCI (0.53) KDM4EGAAALDH1A1GLAPARP1
SCHEMBL3110526 0.68 PRKCI (0.49) KDM4EGAAALDH1A1GLAPARP1
SCHEMBL20066388 0.68 SMN1; SMN2 (0.50) GAAALDH1A1PARP1LMNAPOLB
SCHEMBL28229828 0.67 ALDH1A1 (0.44) KDM4EGAAALDH1A1GLAPARP1
SCHEMBL12852525 0.67 ALDH1A1 (0.44) KDM4EGAAALDH1A1GLAPARP1
Water SCHEMBL1637239 0.66 KDM4E (0.56) KDM4EGAAALDH1A1PARP1PTPN11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630642-B1 Naphthol couplers BRISTOL MYERS SQUIBB CO (US) 1998-08-12 EP disclosed
EP-0630642-A1 Naphthol couplers Bristol-Myers Company (US) 1994-12-28 EP disclosed
US-5344463-A OXIDATION CLAIROL, INC. (US) 1994-09-06 US disclosed