Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 20/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 20/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 20/20 | 0.63 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.59 |
| ▸ | HTR1B | P28222 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541028 | 0.95 | ADRA1D (0.65) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8537142 | 0.94 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL9166798 | 0.92 | ADRA1D (0.72) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8537112 | 0.92 | ADRA1D (0.72) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8544154 | 0.91 | ADRA1D (0.66) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8539253 | 0.91 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8538977 | 0.83 | ADRA1D (0.76) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL6714309 | 0.83 | ADRA1D (0.89) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8542460 | 0.83 | ADRA1D (0.74) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL6714323 | 0.83 | ADRA1D (0.89) | ADRA1DADRA1AADRA1BADRB2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6220015-A | — | — | None | — | — | JP | disclosed |
| EP-0600675-B1 | Indoline compounds for the treatment of dysuria | KISSEI PHARMACEUTICAL (JP) | 1998-07-08 | — | — | EP | disclosed |
| US-5387603-A | Treating dysuria (painful urination) with less hypotension; FDA Orange book listed patent for silodosin | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1995-02-07 | — | — | US | disclosed |
| JP-H06220015-A | INDOLINE DERIVATIVE | KISSEI PHARMACEUT CO LTD | 1994-08-09 | — | — | JP | disclosed |
| EP-0600675-A1 | Indoline compounds for the treatment of dysuria | Kissei Pharmaceutical Co., Ltd. (JP) | 1994-06-08 | — | — | EP | disclosed |