Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537581 | 0.80 | CYP1A2 (0.37) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL8539285 | 0.80 | TAAR1 (0.50) | ALDH1A1MEN1KMT2ACSNK1A1TYRO3 | |
| SCHEMBL1303527 | 0.78 | CSNK1A1 (0.50) | ALDH1A1MEN1KMT2AMAPTCSNK1A1 | |
| SCHEMBL8538728 | 0.78 | MC4R (0.51) | ALDH1A1MEN1KMT2ACSNK1A1TYRO3 | |
| SCHEMBL8539281 | 0.78 | MC4R (0.38) | ALDH1A1MEN1KMT2ACSNK1A1TYRO3 | |
| SCHEMBL8536051 | 0.78 | CSNK1A1 (0.41) | ALDH1A1MEN1KMT2ACSNK1A1TYRO3 | |
| SCHEMBL31753360 | 0.76 | CSNK1A1 (0.42) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL30163620 | 0.76 | TDP1 (0.42) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL8537087 | 0.71 | CSNK1A1 (0.45) | ALDH1A1MEN1KMT2ACSNK1A1TYRO3 | |
| SCHEMBL8540657 | 0.70 | TSHR (0.47) | ALDH1A1MEN1KMT2AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |