Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001368 | 0.81 | NISCH (0.52) | SMN1; SMN2ALDH1A1MEN1KMT2ANISCH | |
| Hydrochloric Acid SCHEMBL29265356 | 0.79 | NISCH (0.50) | SMN1; SMN2ALDH1A1MEN1KMT2ANISCH | |
| SCHEMBL8537581 | 0.79 | CYP1A2 (0.37) | TSHRSMN1; SMN2TDP1GAALMNA | |
| SCHEMBL6051840 | 0.77 | TSHR (0.69) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL4389459 | 0.77 | ALDH1A1 (0.51) | TSHRSMN1; SMN2TDP1MGAMGAA | |
| SCHEMBL28766417 | 0.76 | NISCH (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ANISCH | |
| SCHEMBL1303527 | 0.75 | CSNK1A1 (0.50) | SMN1; SMN2TDP1MGAMGAASI | |
| SCHEMBL9260794 | 0.74 | NISCH (0.46) | TSHRSMN1; SMN2TDP1ALDH1A1MEN1 | |
| SCHEMBL1837259 | 0.73 | NISCH (0.50) | TSHRSMN1; SMN2HSD17B10ALDH1A1MEN1 | |
| SCHEMBL3684600 | 0.73 | NISCH (0.50) | TSHRSMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |