Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL982452 | 0.84 | ELANE (0.65) | CLK1CDK5CDK5R1RAB9AELANE | |
| SCHEMBL5726248 | 0.77 | TDO2 (0.79) | TDO2GSK3BDYRK1ACLK1PIM1 | |
| SCHEMBL8541224 | 0.77 | CYP19A1 (0.53) | MAPTCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8541164 | 0.75 | ELANE (0.56) | CLK1CDK5CDK5R1RAB9AELANE | |
| SCHEMBL31380212 | 0.75 | WEE1 (0.56) | GSK3BDYRK1ACLK1CDK5CDK5R1 | |
| SCHEMBL10338913 | 0.75 | CYP19A1 (0.58) | RAB9AMAPTHPGDCYP19A1CYP11B1 | |
| SCHEMBL13302321 | 0.75 | SLC6A4 (0.52) | CLK1CDK5CDK5R1ELANESLC6A4 | |
| SCHEMBL7811875 | 0.74 | GSK3B (0.76) | TDO2GSK3BDYRK1APIM1PIM3 | |
| SCHEMBL29563549 | 0.74 | GSK3B (0.76) | TDO2GSK3BDYRK1APIM1PIM3 | |
| SCHEMBL2651516 | 0.74 | CYP19A1 (0.54) | GSK3BRAB9ACYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |
| EP-0715627-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | Pfizer Limited (GB) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | disclosed |