Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 5/20 | 0.39 |
| ▸ | CA2 | P00918 | 5/20 | 0.39 |
| ▸ | CA9 | Q16790 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16324628 | 0.84 | LMNA (0.43) | LMNAALDH1A1MAPK1THRBTSHR | |
| SCHEMBL11615284 | 0.82 | LMNA (0.42) | LMNAALDH1A1MAPK1THRBTSHR | |
| SCHEMBL11732763 | 0.82 | LMNA (0.48) | LMNAALDH1A1MAPK1THRBTSHR | |
| SCHEMBL15177300 | 0.81 | LMNA (0.41) | LMNAALDH1A1MAPK1THRBTSHR | |
| SCHEMBL11477968 | 0.80 | LMNA (0.43) | LMNAALDH1A1MAPK1THRBTSHR | |
| SCHEMBL14626532 | 0.80 | LMNA (0.43) | LMNAALDH1A1MAPK1THRBTSHR | |
| SCHEMBL11477962 | 0.80 | LMNA (0.43) | LMNAALDH1A1MAPK1THRBTSHR | |
| Ammonia Solution, Strong SCHEMBL29200990 | 0.80 | LMNA (0.43) | LMNAALDH1A1MAPK1THRBTSHR | |
| SCHEMBL11614983 | 0.79 | LMNA (0.46) | LMNAALDH1A1MAPK1THRBTSHR | |
| SCHEMBL11347175 | 0.78 | LMNA (0.40) | LMNAALDH1A1MAPK1THRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535528-A1 | Antibacterial 5-Nitro-1-methyl-imidazolyl-3-terbutyl-2-hydroxy-aryl-carbinols | EURORESEARCH S.r.L. (IT) | 1993-04-07 | — | — | EP | claimed |
| EP-0103100-B1 | 1-METHYL-5-NITRO-IMIDAZOLINE DERIVATIVES AND THERAPEUTIC COMPOSITIONS WHICH CONTAIN THEM AS ACTIVE PRINCIPLE | EURORESEARCH S.R.L. (IT) | 1987-10-07 | — | — | EP | claimed |
| EP-0103100-A1 | 1-Methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle | EURORESEARCH S.R.L. (IT) | 1984-03-21 | — | — | EP | claimed |
| US-3952007-A | Processes for preparing 5-nitro-1-methyl-2-(2-dialkylaminovinyl)-imidazole and 5-nitro-1-methyl-2-imidazolyl carboxaldehyde | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-04-20 | — | — | US | claimed |
| JP-5194413-A | — | — | None | — | — | JP | disclosed |
| CN-118542865-A | Nitroimidazole compound, pharmaceutical composition and application | 武汉盛云生物医药科技有限责任公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-114380816-B | Nitroimidazole compound, pharmaceutical composition and application | 武汉盛云生物医药科技有限责任公司 | 2024-04-26 | — | — | CN | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| CN-108586434-B | Application of indole-2-ketone compound in antibacterial aspect | 四川大学 | 2020-10-02 | — | — | CN | disclosed |
| WO-2012065527-A1 | COMPOUDS AND USES AS L-TYPE CALCIUM CHANNEL BLOCKER AND/OR ACETYLCHOLINESTERASE INHIBITOR THEREOF | 江苏先声药物研究有限公司 (CN) | 2012-05-24 | — | — | WO | disclosed |
| JP-H05194413-A | 5-NITRO-1-METHYL-IMIDAZOLYL-3-TERT-BUTYL-2-HYDROXY-ARYL CARBINOL, AND PRODUCTION OF ITS PREPARATIONS, AND ASSOCIATED THERAPEUTIC COMPOSITION | EURORESEARCH SRL | 1993-08-03 | — | — | JP | disclosed |
| EP-0535528-A1 | Antibacterial 5-Nitro-1-methyl-imidazolyl-3-terbutyl-2-hydroxy-aryl-carbinols | EURORESEARCH S.r.L. (IT) | 1993-04-07 | — | — | EP | disclosed |
| US-3980794-A | Method for promoting growth of poultry with 3-(5-nitro-2-imidazolyl)pyrazoles | ELI LILLY AND COMPANY (US) | 1976-09-14 | — | — | US | disclosed |
| US-3973019-A | Pharmaceutical compositions containing 1,4-bis-(5'-nitroimidazolyl-2'-methylene-imino) piperazine compounds for treating protozoal diseases and methods for treating such diseases | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-08-03 | — | — | US | disclosed |
| US-3969520-A | 2-Amino-4[2-(1-lower alkyl-5-nitro-2-imidiazolyl)vinyl]pyrimidines for treating protozoal and bacterial infections | ISTITUTO CHEMIOTERAPICO ITALIANO S.P.A. (IT) | 1976-07-13 | — | — | US | disclosed |
| US-3960882-A | IMIDAZOLYLPROPENOIC ACID ESTER | MONTANARI ROBERTO | 1976-06-01 | — | — | US | disclosed |
| US-3952007-A | Processes for preparing 5-nitro-1-methyl-2-(2-dialkylaminovinyl)-imidazole and 5-nitro-1-methyl-2-imidazolyl carboxaldehyde | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-04-20 | — | — | US | disclosed |
| US-3952007-A | Processes for preparing 5-nitro-1-methyl-2-(2-dialkylaminovinyl)-imidazole and 5-nitro-1-methyl-2-imidazolyl carboxaldehyde | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-04-20 | — | — | US | disclosed |
| US-3951963-A | 0-(Substituted-aminoalkyl)-5-nitroimidazole-(2)-aldoximes | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-04-20 | — | — | US | disclosed |
| US-3947467-A | ANTIBACTERIAL, ANTIPROTOZOAL, ANTIFUNGAL | ELI LILLY AND COMPANY (US) | 1976-03-30 | — | — | US | disclosed |