SCHEMBL8538742

SCHEMBL8538742

CCCCc1ccccc1-c1ncc[nH]1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP19A1 P11511 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
CSNK1A1 P48729 1/20 0.44
TYRO3 Q06418 1/20 0.44
DYRK1B Q9Y463 1/20 0.44
NISCH Q9Y2I1 2/20 0.43
MTOR P42345 1/20 0.43
ADK P55263 1/20 0.43
ADRA1A P35348 1/20 0.40
HTR1A P08908 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
MC4R P32245 2/20 0.38
TLR8 Q9NR97 1/20 0.38
IDO1 P14902 1/20 0.38
F2RL1 P55085 5/20 0.36
CASP6 P55212 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15809922 0.95 CYP1A2 (0.47) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL31419337 0.95 CYP1A2 (0.47) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL10414554 0.94 CYP1A2 (0.46) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL8540945 0.85 CSNK1A1 (0.42) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL8614473 0.84 CSNK1A1 (0.48) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL17304239 0.83 CSNK1A1 (0.53) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL8539363 0.82 CSNK1A1 (0.42) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL8537580 0.81 CSNK1A1 (0.44) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9
SCHEMBL6951802 0.81 CSNK1A1 (0.50) CSNK1A1TYRO3DYRK1BNISCHMTOR
SCHEMBL8537907 0.81 CSNK1A1 (0.46) CYP1A2CYP3A4CYP2D6CYP19A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0857171-A2 IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 1998-08-12 EP disclosed
WO-1997015555-A2 IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 1997-05-01 WO disclosed