Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MYB | P10242 | 6/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544137 | 0.90 | MEN1 (0.56) | KMT2AMEN1GAAKDM4EHTT | |
| SCHEMBL14523184 | 0.86 | MYB (0.60) | KMT2AMEN1GAAKDM4EHTT | |
| SCHEMBL9290875 | 0.85 | KMT2A (0.49) | KMT2AMEN1GAAKDM4EHTT | |
| SCHEMBL8543812 | 0.78 | MEN1 (0.67) | KMT2AMEN1MYBALDH1A1MAPT | |
| SCHEMBL5044919 | 0.76 | MYB (0.63) | KMT2AMEN1GAAMYB | |
| SCHEMBL8544234 | 0.74 | MYB (0.75) | KMT2AMEN1GAAKDM4EMYB | |
| SCHEMBL8540816 | 0.68 | MYB (0.41) | KMT2AMEN1GAAKDM4EHTT | |
| SCHEMBL11820276 | 0.68 | KDM4E (0.70) | GAAKDM4EALDH1A1MAPTTSHR | |
| SCHEMBL9120147 | 0.67 | NPSR1 (0.69) | GAAKDM4EHTTALDH1A1NPSR1 | |
| SCHEMBL8271308 | 0.66 | ESR1 (0.79) | KMT2AMEN1KDM4EHTTESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537949-B1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY CO ELI (GB) | 1998-07-01 | — | — | EP | disclosed |
| US-5284868-A | Naphthopyran derivatives; for autoimmune diseases, cancer | ELI LILLY AND COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| US-5281619-A | Administering naphtho(1,2-B)pyran derivatives | ELI LILLY AND COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0537949-A1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY INDUSTRIES LIMITED (GB) | 1993-04-21 | — | — | EP | disclosed |