Terbuthylazine

Terbuthylazine

SCHEMBL8539245

CCNc1nc(Cl)nc(NC(C)(C)C)n1.CCNc1nc(Cl)nc(NC(C)(C)C)n1

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.74
LMNA P02545 5/20 0.73
SMN1; SMN2 Q16637 2/20 0.73
PDE4A P27815 2/20 0.63
CYP1A2 P05177 1/20 0.63
CYP2C19 P33261 1/20 0.63
ALDH1A1 P00352 2/20 0.58
MEN1 O00255 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
CREBBP Q92793 1/20 0.54
GAA P10253 1/20 0.53
NPC1 O15118 2/20 0.51
RAB9A P51151 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Terbuthylazine SCHEMBL9715292 1.00 KMT2A (0.74) KMT2ALMNASMN1; SMN2PDE4ACYP1A2
Terbuthylazine SCHEMBL23642 1.00 KMT2A (0.74) KMT2ALMNASMN1; SMN2PDE4ACYP1A2
Terbuthylazine SCHEMBL29623015 1.00 KMT2A (0.74) KMT2ALMNASMN1; SMN2PDE4ACYP1A2
Terbuthylazine SCHEMBL27492098 0.98 KMT2A (0.72) KMT2ALMNASMN1; SMN2PDE4ACYP1A2
Terbuthylazine SCHEMBL27458672 0.92 KMT2A (0.64) KMT2ALMNASMN1; SMN2PDE4ACYP1A2
Terbuthylazine SCHEMBL9586446 0.90 KMT2A (0.62) KMT2ALMNASMN1; SMN2PDE4ACYP1A2
SCHEMBL19687642 0.90 LMNA (0.68) KMT2ALMNASMN1; SMN2PDE4ACYP1A2
Terbuthylazine SCHEMBL671911 0.89 KMT2A (0.60) KMT2ALMNASMN1; SMN2PDE4ACYP1A2
Terbuthylazine SCHEMBL367486 0.89 KMT2A (0.60) KMT2ALMNASMN1; SMN2PDE4ACYP1A2
Terbutryne SCHEMBL16594385 0.89 KMT2A (0.60) KMT2ALMNASMN1; SMN2PDE4ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0574418-B1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1998-11-11 EP disclosed
US-5688745-A Arylsulfonylureas and their use as herbicides and growth regulators HOECHST AKTIENGESELLSCHAFT (DE) 1997-11-18 US disclosed
US-5624884-A SURFACTANT, ANTIFOAM AMERICAN CYANAMID COMPANY (US) 1997-04-29 US disclosed
US-5463081-A Chemical intermediates HOECHST AKTIENGESELLSCHAFT (DE) 1995-10-31 US disclosed
EP-0575503-A1 HERBICIDAL PYRIDINE SULFONAMIDE E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-12-29 EP disclosed
EP-0574418-A1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS Hoechst Schering AgrEvo GmbH (DE) 1993-12-22 EP disclosed
WO-1992020684-A1 HERBICIDAL OXATRICYCLIC ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-26 WO disclosed
WO-1992015576-A1 HERBICIDAL PYRIDINE SULFONAMIDE E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-09-17 WO disclosed
WO-1992013845-A1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST AKTIENGESELLSCHAFT (DE) 1992-08-20 WO disclosed
WO-1992009587-A1 HERBICIDAL OXAZINE ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-06-11 WO disclosed
WO-1992004827-A1 HERBICIDAL SUBSTITUTED BICYCLIC TRIAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-04-02 WO disclosed