Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | QPCT | Q16769 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9217963 | 0.92 | GSK3B (0.39) | TNFMAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8542424 | 0.85 | KMT2A (0.44) | CYP19A1CYP11B1CYP11B2CNR1MEN1 | |
| SCHEMBL8541102 | 0.79 | TBXAS1 (0.48) | MAPTKMT2A | |
| SCHEMBL8792323 | 0.71 | CNR1 (0.64) | SMN1; SMN2ALDH1A1CNR1POLBLMNA | |
| SCHEMBL8797699 | 0.71 | CNR1 (0.64) | ALDH1A1CNR1IRAK4POLBLMNA | |
| SCHEMBL9337536 | 0.71 | CNR1 (0.52) | TNFMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9334417 | 0.70 | CNR1 (0.63) | TNFSMN1; SMN2ALDH1A1CNR1POLB | |
| SCHEMBL8543283 | 0.70 | TBXAS1 (0.51) | MAPTSMN1; SMN2KDM4EALDH1A1CYP19A1 | |
| SCHEMBL8792292 | 0.70 | CNR1 (0.51) | TNFMAPTRAB9AKDM4ECNR1 | |
| SCHEMBL2125852 | 0.70 | CYP19A1 (0.56) | TNFMAPTRAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |