Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539689 | 1.00 | CYP1A2 (0.53) | CYP1A2CYP3A4MEN1KMT2AKDM4E | |
| SCHEMBL7012222 | 0.88 | CYP1A2 (0.53) | CYP1A2CYP3A4MEN1KMT2AKDM4E | |
| SCHEMBL9195088 | 0.84 | KMT2A (0.51) | CYP1A2CYP3A4MEN1KMT2AKDM4E | |
| SCHEMBL7596958 | 0.82 | KDM4E (0.46) | CYP1A2CYP3A4MEN1KMT2AKDM4E | |
| SCHEMBL8500032 | 0.81 | AKR1C3 (0.49) | CYP1A2MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9192883 | 0.81 | CYP1A2 (0.52) | CYP1A2CYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL3478216 | 0.81 | MAPT (0.56) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL4565884 | 0.80 | HDAC3 (0.57) | CYP1A2CYP3A4MEN1KMT2AKDM4E | |
| SCHEMBL1917678 | 0.80 | LMNA (0.51) | CYP1A2CYP3A4MEN1KMT2AKDM4E | |
| SCHEMBL5110430 | 0.79 | TSHR (0.59) | CYP1A2CYP3A4MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0461039-B1 | Benzimidazole derivatives, process and intermediates for their preparation, their use as medicaments and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-09-16 | — | — | EP | disclosed |
| EP-0461039-A1 | Benzimidazole derivatives, process and intermediates for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1991-12-11 | — | — | EP | disclosed |