Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.70 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | HTR7 | P34969 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11365346 | 0.89 | KCNH2 (0.86) | KCNH2CACNA1GKMT2ALMNAMAPK1 | |
| SCHEMBL8541852 | 0.88 | MAPT (0.61) | MAPK1HTR7MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL8482810 | 0.88 | L3MBTL1 (0.78) | KMT2AMAPK1HTR7MAPTL3MBTL1 | |
| SCHEMBL7882866 | 0.87 | MAPT (0.67) | MAPK1HTR7MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL7159605 | 0.87 | MAPT (0.60) | MAPK1HTR7MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL8541877 | 0.87 | KDM4E (0.69) | KMT2AMAPK1MAPTL3MBTL1DRD4 | |
| SCHEMBL8541479 | 0.86 | MAPT (0.59) | KCNH2CACNA1GMAPK1MAPTL3MBTL1 | |
| SCHEMBL7281725 | 0.84 | KCNH2 (0.69) | KCNH2CACNA1GKMT2ALMNAMAPK1 | |
| SCHEMBL8541454 | 0.84 | ABCB1 (0.59) | KCNH2CACNA1GKMT2AHTR7MAPT | |
| SCHEMBL11370338 | 0.83 | KCNH2 (0.68) | KCNH2CACNA1GKMT2ALMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0485045-B1 | Mono-N-substituted 1,4,7,10-Tetraazacyclododecan-derivatives, process for their preparation and pharmaceutical agent containing them | SCHERING AG (DE) | 1998-12-30 | — | — | EP | disclosed |
| US-5277895-A | Nuclear magnetic resonance | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-01-11 | — | — | US | disclosed |
| EP-0485045-A2 | Mono-N-substituted 1,4,7,10-Tetraazacyclododecan-derivatives, process for their preparation and pharmaceutical agent containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-05-13 | — | — | EP | disclosed |