SCHEMBL8539849

SCHEMBL8539849

CCN(c1ccccc1)c1nc(-n2ccnc2)nc(-n2ccnc2)n1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 13/20 0.74
MAPK1 P28482 7/20 0.70
CYP3A4 P08684 3/20 0.70
L3MBTL1 Q9Y468 2/20 0.70
CYP1A2 P05177 2/20 0.70
CYP2D6 P10635 2/20 0.70
CYP2C9 P11712 2/20 0.70
CYP2C19 P33261 2/20 0.70
NPSR1 Q6W5P4 7/20 0.61
MAPT P10636 6/20 0.61
HTT P42858 5/20 0.61
LMNA P02545 5/20 0.61
TP53 P04637 3/20 0.61
ALDH1A1 P00352 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
HSD17B10 Q99714 1/20 0.61
USP2 O75604 2/20 0.58
ALOX15 P16050 1/20 0.58
HCRTR1 O43613 1/20 0.57
KMT2A Q03164 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8538506 0.88 TSHR (0.65) TSHRMAPK1CYP3A4L3MBTL1CYP1A2
SCHEMBL8538368 0.87 TSHR (0.64) TSHRMAPK1CYP3A4L3MBTL1CYP1A2
SCHEMBL8537006 0.82 TSHR (1.00) TSHRMAPK1CYP3A4L3MBTL1CYP1A2
SCHEMBL8535479 0.78 TSHR (0.58) TSHRMAPK1CYP3A4L3MBTL1CYP1A2
SCHEMBL8536251 0.77 TSHR (0.59) TSHRMAPK1CYP3A4L3MBTL1CYP1A2
SCHEMBL8537386 0.76 TSHR (0.86) TSHRMAPK1CYP3A4L3MBTL1CYP1A2
SCHEMBL13752166 0.76 MAPT (0.73) TSHRMAPK1L3MBTL1CYP1A2CYP2D6
SCHEMBL8535859 0.73 TSHR (0.55) TSHRMAPK1CYP3A4L3MBTL1CYP1A2
SCHEMBL11900640 0.73 TSHR (0.80) TSHRMAPK1CYP3A4L3MBTL1CYP1A2
SCHEMBL8538378 0.73 TSHR (0.64) TSHRMAPK1CYP3A4L3MBTL1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0629622-B1 S-TRIAZINE DERIVATIVE AND REMEDY FOR ESTROGEN-DEPENDENT DISEASES CONTAINING THE SAME AS ACTIVE INGREDIENT ZENYAKU KOGYO KK (JP) 1998-11-11 EP disclosed
US-5489591-A INHIBITORS OF AROMATASE; TREATING ENDOMETRIOSIS, BREAST CANCER CYSTIC OVARIES ZENYAKU KOGYO KABUSHIKI KAISHA (JP) 1996-02-06 US disclosed
EP-0629622-A1 s-TRIAZINE DERIVATIVE AND REMEDY FOR ESTROGEN-DEPENDENT DISEASES CONTAINING THE SAME AS ACTIVE INGREDIENT ZENYAKU KOGYO KABUSHIKIKAISHA (JP) 1994-12-21 EP disclosed