Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.57 |
| ▸ | GPR17 | Q13304 | 4/20 | 0.54 |
| ▸ | FBP1 | P09467 | 1/20 | 0.54 |
| ▸ | RHEB | Q15382 | 5/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1121917 | 0.90 | GRIN1 (0.50) | GRIN1GPR17FBP1RHEBPRKAG1 | |
| SCHEMBL8545427 | 0.76 | RHEB (0.53) | GPR17FBP1RHEBPRKAG1PRKAA2 | |
| SCHEMBL14411936 | 0.74 | GRIN1 (0.47) | GRIN1RHEB | |
| SCHEMBL8541914 | 0.73 | PRKAG1 (0.56) | GPR17FBP1PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL727389 | 0.73 | GRIN1 (1.00) | GRIN1RHEB | |
| SCHEMBL29531428 | 0.73 | GRIN1 (1.00) | GRIN1RHEB | |
| SCHEMBL1590066 | 0.71 | GPR17 (0.57) | GPR17FBP1PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL18299005 | 0.71 | GRIN1 (0.49) | GRIN1GPR17FBP1RHEB | |
| SCHEMBL9156614 | 0.70 | GPR17 (0.59) | GRIN1GPR17FBP1FFAR1 | |
| SCHEMBL8463078 | 0.70 | GPR17 (1.00) | GRIN1GPR17FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483881-B1 | 3-Amidoindolyl derivatives | MERRELL PHARMA INC (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5703107-A | CENTRAL NERVOUS SYSTEM DISORDERS; ANALGESICS; ANTIEPILEPTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-30 | — | — | US | disclosed |
| US-5675018-A | 3-amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5491153-A | 3-amidoindolyl derivative | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| EP-0526478-B1 | 3-INDOLYL THIOACETATE DERIVATIVES | MERRELL DOW PHARMA (US) | 1995-03-15 | — | — | EP | disclosed |
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0526478-A1 | 3-INDOLYL THIOACETATE DERIVATIVES. | MERRELL DOW PHARMA (US) | 1993-02-10 | — | — | EP | disclosed |
| EP-0483881-A1 | 3-Amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| WO-1991016307-A1 | 3-INDOLYL THIOACETATE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| US-5051442-A | 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-09-24 | — | — | US | disclosed |