Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539653 | 0.91 | CYP1A2 (0.47) | ALOX15CYP1A2ALDH1A1HPGDXBP1 | |
| SCHEMBL8538420 | 0.90 | CYP1A2 (0.45) | ALOX15CYP1A2ALDH1A1HPGDXBP1 | |
| SCHEMBL8545145 | 0.87 | CYP1A2 (0.48) | ALOX15CYP1A2ALDH1A1HPGDXBP1 | |
| SCHEMBL8542076 | 0.87 | GRIN1 (0.53) | CYP1A2GRIN1MEN1LMNAMAPK1 | |
| SCHEMBL4339236 | 0.85 | ALOX15 (0.48) | ALOX15CYP1A2ALDH1A1HPGDXBP1 | |
| SCHEMBL8543502 | 0.81 | ALOX15 (0.47) | ALOX15CYP1A2ALDH1A1HPGDXBP1 | |
| SCHEMBL4341044 | 0.80 | CYP1A2 (0.49) | ALOX15CYP1A2ALDH1A1HPGDXBP1 | |
| SCHEMBL8539021 | 0.80 | MEN1 (0.52) | CYP1A2GRIN1MEN1LMNAMAPK1 | |
| SCHEMBL8545605 | 0.79 | ALOX15 (0.48) | ALOX15CYP1A2ALDH1A1HPGDXBP1 | |
| SCHEMBL8540696 | 0.77 | ALOX15 (0.43) | ALOX15CYP1A2ALDH1A1HPGDXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | claimed |
| EP-0483881-B1 | 3-Amidoindolyl derivatives | MERRELL PHARMA INC (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5491153-A | 3-amidoindolyl derivative | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0483881-A1 | 3-Amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-05-06 | — | — | EP | disclosed |