Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546244 | 0.90 | MAPT (0.47) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL8542296 | 0.87 | KMT2A (0.54) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL8545851 | 0.85 | ALOX15 (0.60) | ALDH1A1HPGDALOX15 | |
| SCHEMBL8541953 | 0.82 | ALOX15 (0.48) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL8545593 | 0.82 | KDM4E (0.46) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL19831095 | 0.81 | ALOX15 (0.53) | ALOX15 | |
| SCHEMBL8546241 | 0.80 | ALOX15 (0.43) | MAPTKDM4EALDH1A1HPGDALOX15 | |
| SCHEMBL8540263 | 0.78 | TP53 (0.42) | MAPTKDM4EALDH1A1HPGDALOX15 | |
| SCHEMBL8542952 | 0.77 | KMT2A (0.52) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL8545411 | 0.76 | MAPT (0.53) | MAPTKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483881-B1 | 3-Amidoindolyl derivatives | MERRELL PHARMA INC (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5703107-A | CENTRAL NERVOUS SYSTEM DISORDERS; ANALGESICS; ANTIEPILEPTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-30 | — | — | US | disclosed |
| US-5675018-A | 3-amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5491153-A | 3-amidoindolyl derivative | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0483881-A1 | 3-Amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-05-06 | — | — | EP | disclosed |