Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | APEX1 | P27695 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544209 | 0.88 | APEX1 (0.75) | POLBLMNAAPEX1ALDH1A1 | |
| SCHEMBL8541971 | 0.88 | APEX1 (0.75) | POLBLMNAAPEX1ALDH1A1 | |
| SCHEMBL1001249 | 0.87 | APEX1 (0.73) | POLBAPEX1ALDH1A1KMT2A | |
| SCHEMBL1645604 | 0.86 | APEX1 (0.72) | POLBLMNAKDM4EAPEX1MAPT | |
| SCHEMBL8540145 | 0.85 | APEX1 (0.70) | POLBLMNAAPEX1SMN1; SMN2KMT2A | |
| SCHEMBL7427480 | 0.84 | MAPT (0.66) | POLBLMNAKDM4EAPEX1SMN1; SMN2 | |
| SCHEMBL29483631 | 0.84 | KDM4E (0.77) | POLBLMNAKDM4EALDH1A1PKM | |
| SCHEMBL34615 | 0.83 | MEN1 (0.73) | POLBLMNAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL19667171 | 0.83 | HSD17B10 (0.77) | POLBLMNAKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL8262953 | 0.81 | ALDH1A1 (0.76) | POLBLMNAKDM4EAPEX1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705259-B1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-02-25 | — | — | EP | disclosed |
| EP-0741721-A1 | PHENYLPYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-11-13 | — | — | EP | disclosed |
| EP-0705259-A1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995021165-A1 | PHENYLPYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-08-10 | — | — | WO | disclosed |
| WO-1995000508-A1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-05 | — | — | WO | disclosed |