SCHEMBL8540490

SCHEMBL8540490

O=c1sc2cc3sc(=O)sc3cc2s1

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14030823 0.81 MIF (0.32)
SCHEMBL4563833 0.74
SCHEMBL1157926 0.61
SCHEMBL8849001 0.56
SCHEMBL19436418 0.54
SCHEMBL17104914 0.54
SCHEMBL20042488 0.54 DAO (0.36)
SCHEMBL8358879 0.54
SCHEMBL10758404 0.52
SCHEMBL10982343 0.50

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2872520-B1 TRIARYLMETHYL RADICALS BRACCO IMAGING SPA (IT) 2016-09-14 EP disclosed
US-9381257-B2 Triarylmethyl radicals BRACCO IMAGING S.P.A. (IT) 2016-07-05 US disclosed
US-9381257-B2 Triarylmethyl radicals BRACCO IMAGING S.P.A. (IT) 2016-07-05 US disclosed
US-20150151009-A1 TRIARYLMETHYL RADICALS BRACCO IMAGING S.P.A. (IT) 2015-06-04 US disclosed
US-20150151009-A1 TRIARYLMETHYL RADICALS BRACCO IMAGING S.P.A. (IT) 2015-06-04 US disclosed
WO-2014009240-A1 TRIARYLMETHYL RADICALS BRACCO IMAGING SPA (IT) 2014-01-16 WO disclosed
US-5827501-A INERT TRIARYLMETHYL FREE RADICAL CONTRAST AGENTS FOR ELECTRON SPIN RESONANCE (ESR) ENHANCED MAGNETIC RESONANCE (EMR) IMAGING NYCOMED IMAGING AS (NO) 1998-10-27 US disclosed
US-5599522-A CONTRAST ENHANCING AGENTS NYCOMED IMAGING AS (NO) 1997-02-04 US disclosed
EP-0515458-B1 TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI NYCOMED INNOVATION AB (SE) 1995-08-23 EP disclosed
EP-0515458-A1 TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI. HAFSLUND NYCOMED INNOVATION (SE) 1992-12-02 EP disclosed
WO-1991012024-A1 TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI HAFSLUND NYCOMED INNOVATION AB (SE) 1991-08-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150151009-A1 TRIARYLMETHYL RADICALS MT-ND4L, TXN2, TXNRD2 TDP1 1209/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.