TXN2

Thioredoxin, mitochondrial · Q99757 · TXN2 on Sugi Atlas →

831 patent compounds predicted against TXN2, 677 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Gambogic Acid (SCHEMBL134152)	1.00	1/20
Gambogic Acid (SCHEMBL149213)	1.00	1/20
Gambogic Acid (SCHEMBL3857525)	1.00	1/20
Gambogic Acid (SCHEMBL7946944)	1.00	1/20
Gambogic Acid (SCHEMBL7947021)	1.00	1/20
Gambogic Acid (SCHEMBL12025351)	1.00	1/20
Gambogic Acid (SCHEMBL12025387)	1.00	1/20
Gambogic Acid (SCHEMBL12025441)	1.00	1/20
Gambogic Acid (SCHEMBL12026374)	1.00	1/20
Gambogic Acid (SCHEMBL12045553)	1.00	1/20
Gambogic Acid (SCHEMBL12045554)	1.00	1/20
Gambogic Acid (SCHEMBL12751296)	1.00	1/20
Gambogic Acid (SCHEMBL12859660)	1.00	1/20
Gambogic Acid (SCHEMBL13613351)	1.00	1/20
Gambogic Acid (SCHEMBL13685811)	1.00	1/20
Gambogic Acid (SCHEMBL13685812)	1.00	1/20
Gambogic Acid (SCHEMBL16160279)	1.00	1/20
Gambogic Acid (SCHEMBL1150670)	0.93	1/20
Gambogic Amide (SCHEMBL12751295)	0.89	1/20
Gambogic Amide (SCHEMBL15150010)	0.89	1/20

Clinical trials — most relevant to TXN2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients	PHASE4	UNKNOWN
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept	PHASE3	COMPLETED
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression	PHASE2/PHASE3	NOT_YET_RECRUITING
Coenzyme Q10 in Post-Cardiac Arrest Cerebral Resuscitation	PHASE2	COMPLETED
N-Acetylcysteine for Neuroprotection in Parkinson's Disease	PHASE1/PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease	PHASE2	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Mitochondrial Function of Immune Cells in Sepsis	nan	COMPLETED
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Mitoquines in COPD	nan	UNKNOWN
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Angiogenesis Induced in the Elderly by Hyperbaric Oxygen Therapy	nan	COMPLETED
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)	nan	RECRUITING
Mitochondrial DNA Copy Number and Leukocyte Telomere Length as Biomarkers in Type 2 Diabetic Patients	nan	UNKNOWN
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Human Adaptation to High Altitude	nan	UNKNOWN
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders	nan	RECRUITING
Q10 Ubiquinol in Autism Spectrum Disorder and in Phelan-McDermid Syndrome.	nan	UNKNOWN
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients	nan	UNKNOWN
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)	nan	NOT_YET_RECRUITING
Covid-19: Possible Role of Neutrophil Extracellular Traps	nan	UNKNOWN
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TXN2 binder may also engage these)

Protein	Name	Similarity
P97615	—	1.000	P97615 →
Q95108	—	0.999	Q95108 →
P97493	—	0.996	P97493 →
Q6NPF9	—	0.969	Q6NPF9 →
Q8LD49	—	0.966	Q8LD49 →
P29450	—	0.966	P29450 →
Q0JQ97	—	0.965	Q0JQ97 →
O64764	—	0.965	O64764 →
Q5JMR9	—	0.965	Q5JMR9 →
O48737	—	0.964	O48737 →
Q0JM76	—	0.964	Q0JM76 →
Q17424	—	0.964	Q17424 →
Q6H7E4	—	0.962	Q6H7E4 →
Q7X8R5	—	0.962	Q7X8R5 →
Q9XGS0	—	0.962	Q9XGS0 →
O80800	—	0.960	O80800 →
Q9ZP21	—	0.959	Q9ZP21 →
P07591	—	0.959	P07591 →
P48384	—	0.959	P48384 →
Q9ZP20	—	0.959	Q9ZP20 →
Q41864	—	0.959	Q41864 →
Q9SEU8	—	0.959	Q9SEU8 →
Q9XFH9	—	0.958	Q9XFH9 →
Q8S091	—	0.958	Q8S091 →
Q8L7S9	—	0.958	Q8L7S9 →
O48897	—	0.958	O48897 →
Q8LBK6	—	0.957	Q8LBK6 →
Q9XFH8	—	0.956	Q9XFH8 →
Q84Y95	—	0.956	Q84Y95 →
Q655X0	—	0.955	Q655X0 →