Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.58 |
| ▸ | CTSD | P07339 | 2/20 | 0.57 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269992 | 0.89 | CTSD (0.61) | BACE1CTSD | |
| SCHEMBL8532173 | 0.87 | KLK5 (0.61) | BACE1CTSDKLK5 | |
| SCHEMBL8531207 | 0.87 | KLK5 (0.61) | BACE1CTSDKLK5 | |
| SCHEMBL6447745 | 0.85 | CTSD (0.66) | BACE1CTSDKLK5 | |
| SCHEMBL7268902 | 0.84 | KLK5 (0.61) | BACE1CTSDKLK5 | |
| SCHEMBL7270278 | 0.84 | CTSD (0.67) | BACE1CTSDKLK5 | |
| SCHEMBL7334914 | 0.84 | KLK5 (0.57) | BACE1CTSDKLK5 | |
| SCHEMBL7269733 | 0.83 | KLK5 (0.55) | BACE1CTSDKLK5 | |
| SCHEMBL6449655 | 0.83 | CTSD (0.66) | BACE1CTSDKLK5 | |
| SCHEMBL7270592 | 0.82 | KLK5 (0.63) | KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |