Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 7/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023498 | 0.94 | TBXAS1 (0.58) | TBXAS1HRH4CTSSCTSKSMN1; SMN2 | |
| SCHEMBL8542596 | 0.85 | TBXAS1 (0.61) | TBXAS1PLA2G2A | |
| SCHEMBL8539405 | 0.85 | TBXAS1 (0.53) | TBXAS1HRH4CTSSCTSKCYP19A1 | |
| SCHEMBL8581398 | 0.84 | TBXAS1 (0.53) | TBXAS1CYP19A1PLA2G2ATSHR | |
| SCHEMBL8543963 | 0.79 | TBXAS1 (0.58) | TBXAS1SMN1; SMN2CYP19A1HTT | |
| SCHEMBL9023777 | 0.79 | TBXAS1 (0.61) | TBXAS1HRH4CYP19A1PLA2G2APTGDR2 | |
| SCHEMBL8581448 | 0.77 | TBXAS1 (0.56) | TBXAS1CYP19A1PLA2G2ATSHR | |
| SCHEMBL8544213 | 0.76 | TBXAS1 (0.54) | TBXAS1PLA2G2A | |
| SCHEMBL8544216 | 0.76 | TBXAS1 (0.54) | TBXAS1PLA2G2A | |
| SCHEMBL8541115 | 0.72 | TBXAS1 (0.65) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | disclosed |