Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 14/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544333 | 0.90 | CYSLTR1 (0.52) | GPBAR1FFAR1AKR1B1CYSLTR1CYSLTR2 | |
| SCHEMBL8539274 | 0.81 | GPBAR1 (0.63) | GPBAR1FFAR1AKR1B1CYSLTR1CYSLTR2 | |
| SCHEMBL8544696 | 0.81 | GPBAR1 (0.63) | GPBAR1FFAR1AKR1B1CYSLTR1CYSLTR2 | |
| SCHEMBL9530636 | 0.79 | GPBAR1 (0.62) | GPBAR1CYSLTR1ALOX5 | |
| SCHEMBL7454590 | 0.78 | GPBAR1 (0.74) | GPBAR1FFAR1AKR1B1CYSLTR1CYSLTR2 | |
| SCHEMBL28440788 | 0.77 | MEN1 (0.53) | FFAR1KDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9828714 | 0.75 | FFAR1 (0.67) | GPBAR1FFAR1AKR1B1CYSLTR1CYSLTR2 | |
| SCHEMBL9022146 | 0.75 | GPBAR1 (0.66) | GPBAR1FFAR1AKR1B1CYSLTR1CYSLTR2 | |
| SCHEMBL9828160 | 0.74 | CYSLTR1 (0.72) | GPBAR1FFAR1AKR1B1CYSLTR1CYSLTR2 | |
| SCHEMBL8543455 | 0.74 | CYSLTR1 (0.61) | GPBAR1CYSLTR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539117-B1 | Compounds useful as leukotriene antagonists | LILLY CO ELI (GB) | 1998-03-11 | — | — | EP | disclosed |
| US-5410061-A | Leukotriene antagonist | LILLY INDUSTRIES LIMITED (GB) | 1995-04-25 | — | — | US | disclosed |
| EP-0539117-A1 | Compounds useful as leukotriene antagonists | LILLY INDUSTRIES LIMITED (GB) | 1993-04-28 | — | — | EP | disclosed |