Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.62 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539274 | 0.95 | GPBAR1 (0.63) | GPBAR1CYSLTR1ALOX5 | |
| SCHEMBL8544696 | 0.90 | GPBAR1 (0.63) | GPBAR1CYSLTR1ALOX5 | |
| SCHEMBL8543455 | 0.84 | CYSLTR1 (0.61) | GPBAR1CYSLTR1ALOX5 | |
| SCHEMBL9529112 | 0.83 | FFAR1 (0.62) | GPBAR1CYSLTR1 | |
| SCHEMBL9209634 | 0.82 | CYSLTR1 (0.59) | GPBAR1CYSLTR1ALOX5 | |
| SCHEMBL9209653 | 0.80 | GPBAR1 (0.53) | GPBAR1CYSLTR1ALOX5 | |
| SCHEMBL8540828 | 0.79 | GPBAR1 (0.54) | GPBAR1CYSLTR1ALOX5 | |
| SCHEMBL7718896 | 0.78 | GPBAR1 (0.90) | GPBAR1CYSLTR1ALOX5 | |
| SCHEMBL7457682 | 0.78 | GPBAR1 (0.90) | GPBAR1CYSLTR1ALOX5 | |
| SCHEMBL7801672 | 0.78 | GPBAR1 (0.85) | GPBAR1CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |