Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 16/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541003 | 1.00 | TBXAS1 (0.55) | TBXAS1CYP1A2USP2LMNAMEN1 | |
| SCHEMBL8541166 | 0.82 | TBXAS1 (0.66) | TBXAS1 | |
| SCHEMBL8544213 | 0.81 | TBXAS1 (0.54) | TBXAS1CYP1A2USP2LMNAMEN1 | |
| SCHEMBL8544216 | 0.81 | TBXAS1 (0.54) | TBXAS1CYP1A2USP2LMNAMEN1 | |
| SCHEMBL8582880 | 0.81 | TBXAS1 (0.56) | TBXAS1CYP19A1 | |
| SCHEMBL8544303 | 0.81 | PTGDR2 (0.52) | TBXAS1MEN1KMT2A | |
| SCHEMBL8544309 | 0.81 | PTGDR2 (0.52) | TBXAS1MEN1KMT2A | |
| SCHEMBL8582800 | 0.80 | TBXAS1 (0.55) | TBXAS1CYP19A1 | |
| SCHEMBL8543306 | 0.75 | TBXAS1 (0.85) | TBXAS1 | |
| SCHEMBL8539405 | 0.75 | TBXAS1 (0.53) | TBXAS1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| EP-0715627-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | Pfizer Limited (GB) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | disclosed |