Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.50 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542023 | 0.91 | GRIN1 (0.53) | GRIN1GPR17FBP1MEN1LMNA | |
| SCHEMBL8540279 | 0.88 | ALOX15 (0.46) | GRIN1MEN1CYP1A2BLMPMP22 | |
| SCHEMBL8542914 | 0.85 | GRIN1 (0.47) | GRIN1GPR17FBP1MEN1LMNA | |
| SCHEMBL4332699 | 0.84 | GRIN1 (0.54) | GRIN1GPR17FBP1 | |
| SCHEMBL4480901 | 0.83 | GRIN1 (0.56) | GRIN1GPR17FBP1MEN1LMNA | |
| SCHEMBL9583013 | 0.81 | GRIN1 (0.60) | GRIN1GPR17FBP1MEN1LMNA | |
| SCHEMBL8539185 | 0.80 | GRIN1 (0.49) | GRIN1GPR17FBP1MEN1LMNA | |
| SCHEMBL8538972 | 0.79 | ALOX15 (0.47) | GRIN1MEN1CYP1A2BLMPMP22 | |
| SCHEMBL8540376 | 0.78 | GPR17 (0.47) | GRIN1GPR17FBP1MEN1LMNA | |
| SCHEMBL8539028 | 0.77 | GRIN1 (0.54) | GRIN1GPR17FBP1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | claimed |
| EP-0483881-B1 | 3-Amidoindolyl derivatives | MERRELL PHARMA INC (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5703107-A | CENTRAL NERVOUS SYSTEM DISORDERS; ANALGESICS; ANTIEPILEPTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-30 | — | — | US | disclosed |
| US-5675018-A | 3-amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5491153-A | 3-amidoindolyl derivative | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0483881-A1 | 3-Amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-05-06 | — | — | EP | disclosed |