Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 2/20 | 0.57 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | CA3 | P07451 | 3/20 | 0.51 |
| ▸ | CA4 | P22748 | 3/20 | 0.51 |
| ▸ | CA6 | P23280 | 3/20 | 0.51 |
| ▸ | CA5A | P35218 | 3/20 | 0.51 |
| ▸ | CA7 | P43166 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.51 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543042 | 1.00 | CYP26A1 (0.57) | CYP26A1CYP26B1MAOBKDM4EALDH1A1 | |
| SCHEMBL8545402 | 0.88 | KDM4E (0.51) | CYP26A1CYP26B1MAOBKDM4EALDH1A1 | |
| SCHEMBL8545404 | 0.88 | KDM4E (0.51) | CYP26A1CYP26B1MAOBKDM4EALDH1A1 | |
| SCHEMBL6071061 | 0.84 | TTR (0.57) | MAOBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL6071058 | 0.84 | TTR (0.57) | MAOBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL34460082 | 0.80 | CYP26A1 (0.64) | CYP26A1CYP26B1KDM4EALDH1A1MAPT | |
| SCHEMBL27254464 | 0.80 | CYP26A1 (0.51) | CYP26A1CYP26B1KDM4EALDH1A1MAPT | |
| SCHEMBL34460073 | 0.77 | CYP26B1 (0.73) | CYP26A1CYP26B1KDM4EALDH1A1MAPT | |
| SCHEMBL4074346 | 0.76 | CYP2A6 (0.53) | MAOBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL889007 | 0.76 | TDP1 (0.47) | CYP26A1CYP26B1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |
| EP-0715627-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | Pfizer Limited (GB) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | disclosed |