Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | CA3 | P07451 | 3/20 | 0.51 |
| ▸ | CA4 | P22748 | 3/20 | 0.51 |
| ▸ | CA6 | P23280 | 3/20 | 0.51 |
| ▸ | CA5A | P35218 | 3/20 | 0.51 |
| ▸ | CA7 | P43166 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.51 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.51 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.51 |
| ▸ | DPP4 | P27487 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545402 | 1.00 | KDM4E (0.51) | KDM4EHSD17B10MAPK1ALDH1A1HPGD | |
| SCHEMBL8543042 | 0.88 | CYP26A1 (0.57) | KDM4EHSD17B10MAPK1ALDH1A1HPGD | |
| SCHEMBL8543036 | 0.88 | CYP26A1 (0.57) | KDM4EHSD17B10MAPK1ALDH1A1HPGD | |
| SCHEMBL28569699 | 0.79 | RELA (0.52) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL30460284 | 0.76 | CYP2A6 (0.52) | KDM4EALDH1A1CA12CA9GAA | |
| SCHEMBL755207 | 0.75 | KDM4E (0.64) | KDM4EHSD17B10MAPK1ALDH1A1HPGD | |
| SCHEMBL8746669 | 0.75 | KDM4E (0.64) | KDM4EHSD17B10MAPK1ALDH1A1HPGD | |
| SCHEMBL23245359 | 0.75 | GPR183 (0.38) | KDM4EMAPK1ALDH1A1HPGDCA12 | |
| SCHEMBL23245362 | 0.75 | GPR183 (0.38) | KDM4EMAPK1ALDH1A1HPGDCA12 | |
| SCHEMBL8802592 | 0.75 | HDAC1 (0.45) | KDM4EHSD17B10MAPK1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |
| EP-0715627-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | Pfizer Limited (GB) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | disclosed |