Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547401 | 0.89 | BCHE (0.46) | BCHEACHEKDM4EALDH1A1LMNA | |
| SCHEMBL8546027 | 0.88 | KIT (0.40) | KITPDGFRAFGFR3BCHEACHE | |
| SCHEMBL24277208 | 0.85 | KIT (0.40) | KITPDGFRAFGFR3BCHEACHE | |
| SCHEMBL24277211 | 0.85 | KIT (0.40) | KITPDGFRAFGFR3BCHEACHE | |
| Dimethylamine SCHEMBL8546032 | 0.85 | KIT (0.44) | KITPDGFRAFGFR3BCHEACHE | |
| Dimethylamine SCHEMBL7640258 | 0.84 | KIT (0.43) | KITPDGFRAFGFR3BCHEACHE | |
| SCHEMBL29371790 | 0.83 | KIT (0.45) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| SCHEMBL28056 | 0.83 | KIT (0.45) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| SCHEMBL29435144 | 0.83 | KIT (0.45) | KITPDGFRAFGFR3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5953239 | 0.83 | KIT (0.45) | KITPDGFRAFGFR3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591058-B1 | Ellipticine derivatives with antitumor activity | ADIR (FR) | 1998-06-03 | — | — | EP | claimed |
| US-5407940-A | Antitumor agents | ADIR ET COMPAGNIE (FR) | 1995-04-18 | — | — | US | claimed |
| EP-0591058-A1 | Ellipticine derivatives with antitumor activity | ADIR ET COMPAGNIE (FR) | 1994-04-06 | — | — | EP | claimed |
| EP-0591058-B1 | Ellipticine derivatives with antitumor activity | ADIR (FR) | 1998-06-03 | — | — | EP | disclosed |
| US-5498611-A | ANTITUMOR AGENTS | ADIR ET COMPAGNIE (FR) | 1996-03-12 | — | — | US | disclosed |
| US-5407940-A | Antitumor agents | ADIR ET COMPAGNIE (FR) | 1995-04-18 | — | — | US | disclosed |
| EP-0591058-A1 | Ellipticine derivatives with antitumor activity | ADIR ET COMPAGNIE (FR) | 1994-04-06 | — | — | EP | disclosed |