Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | WNT1 | P04628 | 4/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9091784 | 0.89 | KDM4E (0.54) | PARP1KMT2AKDM4ELMNAMAPT | |
| Dimethylamine SCHEMBL8550040 | 0.84 | KIT (0.44) | KDM4EKITPDGFRAFGFR3 | |
| SCHEMBL8547397 | 0.83 | KIT (0.44) | PARP1KMT2AKDM4EWNT1DYRK1A | |
| Dimethylamine SCHEMBL8548190 | 0.82 | KIT (0.46) | KITPDGFRAFGFR3 | |
| SCHEMBL8550032 | 0.82 | BRAF (0.49) | KMT2AKDM4EWNT1DYRK1AKIT | |
| SCHEMBL8547279 | 0.81 | KMT2A (0.42) | KMT2AKDM4EMAPTWNT1DYRK1A | |
| SCHEMBL8548184 | 0.75 | KIT (0.44) | CYP1A2CYP2D6KITPDGFRAFGFR3 | |
| SCHEMBL24277030 | 0.75 | KIT (0.42) | CYP1A2CYP2D6KITPDGFRAFGFR3 | |
| SCHEMBL8550027 | 0.75 | KIT (0.42) | CYP1A2CYP2D6KITPDGFRAFGFR3 | |
| SCHEMBL24277001 | 0.74 | KIT (0.57) | KMT2AKDM4EMAPTDYRK1AKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498611-A | ANTITUMOR AGENTS | ADIR ET COMPAGNIE (FR) | 1996-03-12 | — | — | US | claimed |
| EP-0591058-B1 | Ellipticine derivatives with antitumor activity | ADIR (FR) | 1998-06-03 | — | — | EP | disclosed |
| US-5498611-A | ANTITUMOR AGENTS | ADIR ET COMPAGNIE (FR) | 1996-03-12 | — | — | US | disclosed |
| US-5407940-A | Antitumor agents | ADIR ET COMPAGNIE (FR) | 1995-04-18 | — | — | US | disclosed |
| EP-0591058-A1 | Ellipticine derivatives with antitumor activity | ADIR ET COMPAGNIE (FR) | 1994-04-06 | — | — | EP | disclosed |