Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547397 | 0.94 | KIT (0.44) | BRAFKITKDM4EALDH1A1HPGD | |
| SCHEMBL9091811 | 0.88 | KIT (0.59) | BRAFKITKDM4EALDH1A1HPGD | |
| Dimethylamine SCHEMBL8550040 | 0.86 | KIT (0.44) | BRAFKITKDM4EPDGFRAFGFR3 | |
| Dimethylamine SCHEMBL8548190 | 0.84 | KIT (0.46) | BRAFKITPDGFRAFGFR3 | |
| SCHEMBL1061365 | 0.83 | KIT (0.64) | BRAFKITPOLBPDGFRAFGFR3 | |
| SCHEMBL8547834 | 0.83 | KIT (0.56) | BRAFKITKDM4EALDH1A1HPGD | |
| SCHEMBL8543769 | 0.82 | CYP1A2 (0.45) | KITKDM4EHSD17B10KMT2APDGFRA | |
| SCHEMBL24277030 | 0.81 | KIT (0.42) | BRAFKITALDH1A1HPGDPDGFRA | |
| SCHEMBL8548184 | 0.80 | KIT (0.44) | BRAFKITHPGDPDGFRAFGFR3 | |
| SCHEMBL8550027 | 0.80 | KIT (0.42) | BRAFKITHPGDPDGFRAFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591058-B1 | Ellipticine derivatives with antitumor activity | ADIR (FR) | 1998-06-03 | — | — | EP | disclosed |
| US-5498611-A | ANTITUMOR AGENTS | ADIR ET COMPAGNIE (FR) | 1996-03-12 | — | — | US | disclosed |
| US-5407940-A | Antitumor agents | ADIR ET COMPAGNIE (FR) | 1995-04-18 | — | — | US | disclosed |
| EP-0591058-A1 | Ellipticine derivatives with antitumor activity | ADIR ET COMPAGNIE (FR) | 1994-04-06 | — | — | EP | disclosed |