Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545213 | 0.87 | CYP1A2 (0.42) | KDM4EMAPT | |
| SCHEMBL8540781 | 0.87 | KDM4E (0.36) | POLBLMNAKDM4EMEN1KMT2A | |
| SCHEMBL8544128 | 0.80 | POLB (0.37) | POLBGAAMAPT | |
| SCHEMBL9374984 | 0.80 | TNKS (0.35) | KDM4EMEN1KMT2AIKBKBCHUK | |
| SCHEMBL8540727 | 0.80 | HTR2C (0.40) | POLBKDM4EGAAMAPT | |
| SCHEMBL8538103 | 0.78 | HTR2C (0.39) | KDM4EMAPT | |
| SCHEMBL8588425 | 0.78 | LMNA (0.34) | POLBLMNAMAPT | |
| SCHEMBL8537925 | 0.78 | MAPT (0.41) | KDM4EMAPT | |
| SCHEMBL8539254 | 0.78 | KDM4E (0.35) | LMNAKDM4EMAPT | |
| SCHEMBL8542811 | 0.77 | MAPT (0.35) | POLBKDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2668163-B2 | — | — | 1997-10-27 | — | — | JP | claimed |
| US-5565472-A | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents | PFIZER INC. (US) | 1996-10-15 | — | — | US | claimed |
| WO-1993015058-A1 | 4-ARYL-3-(HETEROARYLUREIDO)-1,2-DIHYDRO-2-OXO-QUINOLINE DERIVATIVES AS ANTIHYPERCHOLESTEROLEMIC AND ANTIATHEROSCLEROTIC AGENTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | claimed |
| EP-0623112-B1 | 4-Phenyl-3-(heteroarylureido)-1,2-dihydro-2-oxoquinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents | PFIZER (US) | 1998-12-30 | — | — | EP | disclosed |
| US-5565472-A | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents | PFIZER INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0623112-A1 | 4-ARYL-3-(HETEROARYLUREIDO)-1,2-DIHYDRO-2-OXO-QUINOLINE DERIVATIVES AS ANTIHYPERCHOLESTEROLEMIC AND ANTIATHEROSCLEROTIC AGENTS | PFIZER INC. (US) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993015058-A1 | 4-ARYL-3-(HETEROARYLUREIDO)-1,2-DIHYDRO-2-OXO-QUINOLINE DERIVATIVES AS ANTIHYPERCHOLESTEROLEMIC AND ANTIATHEROSCLEROTIC AGENTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |