Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.46 |
| ▸ | SMO | Q99835 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543077 | 0.89 | BCHE (0.68) | BCHESLC6A2ACHE | |
| SCHEMBL8544182 | 0.88 | BCHE (0.67) | BCHESLC6A2ACHE | |
| SCHEMBL8543035 | 0.86 | SLC6A2 (0.64) | BCHESLC6A2NPY5R | |
| SCHEMBL8539188 | 0.84 | BCHE (0.55) | BCHESLC6A2SMO | |
| SCHEMBL7609605 | 0.83 | BCHE (0.68) | BCHESLC6A2ACHE | |
| SCHEMBL8543076 | 0.81 | BCHE (0.66) | BCHESLC6A2ACHEKDM4C | |
| SCHEMBL8539754 | 0.80 | BCHE (1.00) | BCHESLC6A2ACHEKDM4C | |
| Nerispirdine SCHEMBL3842518 | 0.80 | SLC6A2 (0.67) | BCHESLC6A2 | |
| Nerispirdine SCHEMBL29379158 | 0.80 | SLC6A2 (0.67) | BCHESLC6A2 | |
| SCHEMBL8543725 | 0.80 | BCHE (0.63) | BCHESLC6A2ACHEROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468401-B1 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0468401-A2 | 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-29 | — | — | EP | disclosed |