SCHEMBL8544873

SCHEMBL8544873

O=C(Cc1cnccn1)c1ccccc1.O=C(Cc1cnccn1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.56
VNN1 O95497 1/20 0.55
PLOD2 O00469 2/20 0.53
RAB9A P51151 4/20 0.51
NPC1 O15118 3/20 0.51
ALDH1A1 P00352 4/20 0.49
HPGD P15428 3/20 0.49
CYP1A2 P05177 2/20 0.49
CYP2C19 P33261 2/20 0.49
CYP2C9 P11712 2/20 0.49
CYP3A4 P08684 2/20 0.49
PLOD3 O60568 1/20 0.49
CYP2D6 P10635 1/20 0.49
PLOD1 Q02809 1/20 0.49
HIF1A Q16665 1/20 0.49
SMN1; SMN2 Q16637 4/20 0.47
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
CTNNB1 P35222 1/20 0.46
WNT3A P56704 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1515801 1.00 IDO1 (0.56) IDO1VNN1PLOD2RAB9ANPC1
SCHEMBL10906953 0.83 IDO1 (0.47) IDO1RAB9ANPC1ALDH1A1SMN1; SMN2
SCHEMBL10906842 0.83 RAB9A (0.65) IDO1PLOD2RAB9ANPC1ALDH1A1
SCHEMBL10908679 0.83 RAB9A (0.65) IDO1RAB9ANPC1ALDH1A1HPGD
SCHEMBL6011931 0.80 RAB9A (0.75) IDO1PLOD2RAB9ANPC1ALDH1A1
SCHEMBL2051943 0.80 RAB9A (0.75) IDO1PLOD2RAB9ANPC1ALDH1A1
SCHEMBL21505337 0.80 IDO1 (0.53) IDO1VNN1RAB9ANPC1ALDH1A1
SCHEMBL11822819 0.80 SYK (0.54) RAB9ANPC1ALDH1A1HPGDSMN1; SMN2
SCHEMBL15572404 0.80 IDO1 (0.48) IDO1VNN1ALDH1A1CYP1A2CYP2C19
Hydrochloric Acid SCHEMBL11622188 0.79 RAB9A (0.73) IDO1PLOD2RAB9ANPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0715624-B1 PROCESS FOR THE PREPARATION OF BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE YAMANOUCHI PHARMA CO LTD (JP) 1998-04-08 EP disclosed