Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544991 | 1.00 | MEN1 (0.41) | MEN1KMT2ACARM1PRMT6KDM4E | |
| SCHEMBL8543130 | 1.00 | MEN1 (0.41) | MEN1KMT2ACARM1PRMT6KDM4E | |
| SCHEMBL8591795 | 0.93 | CARM1 (0.43) | CARM1PRMT6GRIN2BBCHECCR2 | |
| SCHEMBL8548407 | 0.93 | CARM1 (0.43) | CARM1PRMT6GRIN2BBCHECCR2 | |
| SCHEMBL8545545 | 0.87 | CARM1 (0.39) | MEN1KMT2ACARM1PRMT6KDM4E | |
| SCHEMBL8543294 | 0.86 | CARM1 (0.40) | MEN1KMT2ACARM1PRMT6KDM4E | |
| SCHEMBL8541668 | 0.85 | GRIN2B (0.51) | MEN1KMT2AKDM4EGRIN2BCYP2C9 | |
| SCHEMBL8543293 | 0.83 | CARM1 (0.39) | MEN1KMT2ACARM1PRMT6KDM4E | |
| SCHEMBL8549242 | 0.83 | CARM1 (0.39) | MEN1KMT2ACARM1PRMT6KDM4E | |
| SCHEMBL8544591 | 0.83 | CARM1 (0.39) | MEN1KMT2ACARM1PRMT6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| US-5698553-A | Benzylpiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-16 | — | — | US | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |