Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | CASP1 | P29466 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543558 | 0.85 | ALDH1A1 (0.53) | ALDH1A1LMNACASP1KMT2AMEN1 | |
| SCHEMBL8545070 | 0.84 | ALDH1A1 (0.70) | ALDH1A1LMNACASP1KMT2AMEN1 | |
| SCHEMBL8545128 | 0.83 | MAPT (0.56) | ALDH1A1LMNACASP1KMT2AMEN1 | |
| SCHEMBL8547862 | 0.81 | ALDH1A1 (0.52) | ALDH1A1LMNACASP1KMT2AMEN1 | |
| SCHEMBL8547334 | 0.81 | MAPT (0.51) | ALDH1A1LMNACASP1KMT2AMEN1 | |
| SCHEMBL8543359 | 0.80 | ALDH1A1 (0.51) | ALDH1A1LMNACASP1KMT2AMEN1 | |
| SCHEMBL8546711 | 0.80 | KMT2A (0.52) | ALDH1A1LMNACASP1KMT2AMEN1 | |
| SCHEMBL8543522 | 0.79 | MAPT (0.54) | ALDH1A1LMNACASP1KMT2AMEN1 | |
| SCHEMBL8549772 | 0.79 | ALDH1A1 (0.55) | ALDH1A1LMNAKMT2AMEN1MAPT | |
| SCHEMBL8543723 | 0.78 | ALDH1A1 (0.51) | ALDH1A1LMNAKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557075-B1 | 4H-naphtho 1,2-b pyran derivatives as antiproliferative agents | LILLY CO ELI (GB) | 1998-06-24 | — | — | EP | disclosed |
| US-5663375-A | CELL PROLIFERATION | ELI LILLY AND COMPANY (US) | 1997-09-02 | — | — | US | disclosed |
| US-5622987-A | PREVENT MIGRATION OR PROLIFERATION OF SMOOTH MUSCLE CELLS | ELI LILLY AND COMPANY (US) | 1997-04-22 | — | — | US | disclosed |
| US-5378699-A | Treatment of immune diseases, cell proliferation, restenosis and smooth muscle cells | LILLY INDUSTRIES LIMITED (GB) | 1995-01-03 | — | — | US | disclosed |
| US-5378717-A | Therapy for diabetic complications | ELI LILLY AND COMPANY (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0557075-A1 | 4H-naphtho 1,2-b pyran derivatives as antiproliferative agents | LILLY INDUSTRIES LIMITED (GB) | 1993-08-25 | — | — | EP | disclosed |