SCHEMBL8545396

SCHEMBL8545396

CCOC(=O)CCC1(C)C=Cc2cc(OCCc3ccc(C#N)cc3)ccc2O1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 3/20 0.39
PPARA Q07869 3/20 0.39
MAOB P27338 1/20 0.36
BACE1 P56817 1/20 0.36
FFAR1 O14842 1/20 0.36
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GAA P10253 1/20 0.36
HPGD P15428 1/20 0.36
CASP1 P29466 1/20 0.36
HSD17B10 Q99714 1/20 0.36
HRH2 P25021 1/20 0.35
HRH1 P35367 1/20 0.35
HRH3 Q9Y5N1 1/20 0.35
MAPT P10636 1/20 0.35
LTA4H P09960 3/20 0.35
ALK Q9UM73 1/20 0.34
PPARG P37231 1/20 0.34
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6957558 0.92 MAOB (0.45) PPARDPPARAMAOBBACE1FFAR1
SCHEMBL6958002 0.78 BACE1 (0.40) BACE1FFAR1ALDH1A1KDM4EGAA
Hydrochloric Acid SCHEMBL6949114 0.76 F2 (0.43) PPARDPPARAPPARG
Hydrochloric Acid SCHEMBL6949120 0.76 PPARG (0.42) PPARDPPARABACE1ALDH1A1KDM4E
SCHEMBL6948888 0.72 MAPT (0.47) BACE1ALDH1A1KDM4EGAAMAPT
SCHEMBL15970987 0.71 MMP2 (0.59) ALDH1A1HRH2HRH1HRH3MAPT
SCHEMBL6954418 0.70 MAOB (0.56) PPARDPPARAMAOBALDH1A1KDM4E
SCHEMBL6328916 0.70 MAPT (0.55) ALDH1A1HRH2HRH1HRH3MAPT
SCHEMBL4506493 0.70 CYP4F2 (0.66) FFAR1ALDH1A1HSD17B10HRH3MAPT
SCHEMBL6958499 0.70 PPARG (0.45) PPARDPPARAMAOBALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0804431-A4 GLYCOPROTEIN IIb/IIIa ANTAGONISTS LILLY CO ELI (US) 1998-04-29 EP disclosed
EP-0804431-A1 GLYCOPROTEIN IIb/IIIa ANTAGONISTS ELI LILLY AND COMPANY (US) 1997-11-05 EP disclosed